A series of novel 2-amino-4-pyrazolecyclopentylpyrimidines have been prepared and evaluated as IGF-1R tyrosin kinase inhibitors. The in vitro activity was found to depend strongly on the substitution pattern in the 2- amino ring, 4-pyrazolo moieties …
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating Insulin-Like Growth Factor I Receptor and Insulin Receptor. The compounds of the instant invention possess a core structure that comprises a …