Immunogenetics of respiratory disorders

Background Asthma is a complex disorder of the airways of the lungs. TGF-β1 plays a key role in airway remodeling and asthma by having both proinflammatory and anti-inflammatory activities, making TGFβ1 an important candidate gene to study. Objective …

We conducted a case‐control study aimed at identifying polymorphisms and haplotypes in the FcεRIβ gene associated with asthma and its associated phenotypes such as serum IgE levels. A G/A polymorphism in intron 2, a (CA)n repeat polymorphism in …

In this paper, we report for the first time the results of an investigation on the association of signal transducer and activator of transcription 6 (STAT6) with asthma in the Indian population. A novel polymorphic CA-repeat in the proximal promoter …

Epidemiologic studies in India show that the prevalence of asthma is increasing, but no genetic studies have been reported on the Indian population thus far. We selected the IFNG locus on 12q21 as a candidate gene for asthma on the basis of its role …