Experience

Multidisciplinary work in drug discovery involving statistics, mathematics, computational methods, medicinal chemistry, pharmacology, pharmacokinetics, toxicology :

Review of project data at different stages for go-no go decision-making

Assessment of external project, collaboration and service proposals involving computational methods in silico toxicity predictions of compounds for regulatory submission in silico property predictions for pharmaceutics applications in silico prediction of metabolites of a compound New drug target assessment Set-up and management of computational drug discovery facility Cheminformatics integration and continuous inputs to drug discovery projects Structure-based drug design and continuous inputs to drug discovery projects Creation of scientific databases for internal use Biostatistical analysis of data Multivariate statistical analysis Initiation & management of NCE project from virtual hits to optimized leads

Publications in Drug Discovery Today, ChemMedChem, J Med Chem, Euro J Pharmacol, Bioorg Med Chem, Bioorg Med Chem Lett, Euro J Med Chem

Played advisory role for small companies on application of HPC and computational services in drug discovery

Guided a number of Intern projects for Biotech/Bioinformatics students from IIT(Delhi), statistics students from IIT(Bombay), MCA and Bioinformatics students from various institutes.

Guest faculty in workshops on Statistics, Bioinformatics and in silico drug discovery.

Organized Workshop on Mathematics in Drug Discovery as part of DST-IISc Year of Mathbio, 2010.

Member of group actively promoting mathematical and computational biology (more broadly, lifesciences) in India.

Scientific direction of computational drug discovery applications in NCE projects. Initiate & manage new projects. Scientific, Technical and people management.

Set-up computational drug discovery facility. Initiate & manage projects.

Multidisciplinary work involving application of statistics and computational methods to biology and medicine: Initiated and implemented new projects in Genome Informatics Disease genomics - asthma, neuropsychiatric disorders, diabetes Preparation of questionnaires for collection of patient data for genetic correlation Metabolic and signalling pathway database creation & modeling Interaction with clinicians and molecular biologists Ayurvedic prakriti assessment project Guided undergraduate, graduate and doctoral students' projects Genome informatics lab set-up & management, software development

Publications in Hum Heredity, J Allergy & Clin Immunol, Biol Psychiatry, Am J Resp Cell Mol Biol, Mol Biol Evol, Am J Med Genet, Pharmacogenomics etc.

Co-author in 3 patents.

Faculty in workshops on Bioinformatics etc. Guest Faculty at IIT Delhi & ACBR, Delhi University.

Guest lectures in Biostatistics, Research Guidance to summer interns, undergraduates etc.

Taught full courses in statistical genetics, multivariate statistics, Biostatistics to Masters students in Statistics and Biotechnology departments. Guest lectures to MSc Bioinformatics. Faculty in workshops on statistics, DNA fingerprinting etc.

Developed expertise in phylogenetic analysis and statistical applications to DNA fingerprinting. Initiated and implemented novel project on map-representation of phylogenetic relationships.

Faculty in DST & other government funded Workshops on Evolutionary Biology, DNA fingerprinting etc.

Publications in J Biosci, J Fish Biol.

Worked on map-representation of immune network data. Published paper “Inverse Analysis of Empirical Matrices of Idiotypic-network Interactions.” in Bull. Math Biol.